abstract：BACKGROUND:The Parent Cough-Specific Quality-of-Life questionnaire (PC-QOL) has relevance and clinical utility as a cough-specific QOL measure for pediatric use. Its validity has been demonstrated. This study sought to determine the minimally important difference (MID) for the PC-QOL completed by parents of young child...

journal_title：Chest

authors： Newcombe PA,Sheffield JK,Chang AB

更新日期：2011-03-01 00:00:00

abstract：:Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permane...

journal_title：Chest

authors： Martino D,Prescott S

更新日期：2011-03-01 00:00:00

abstract：:We describe an unusual case of orthodeoxia platypnea syndrome exacerbated by right ventricular inflow obstruction due to iatrogenic steroid-induced adipose deposition in cardiac tissues. A 68-year-old man on long-term prednisone therapy for eosinophilic pneumonia presented with progressive dyspnea worsened by bending ...

journal_title：Chest

authors： Bokhari SSI,Willens HJ,Lowery MH,Wanner A,deMarchena E

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Bedside ultrasound examination could be used to assess jugular venous pressure (JVP), and thus central venous pressure (CVP), more reliably than clinical examination. METHODS:The study was a prospective, blinded evaluation comparing physical examination of external jugular venous pressure (JVPEXT), internal...

journal_title：Chest

authors： Deol GR,Collett N,Ashby A,Schmidt GA

更新日期：2011-01-01 00:00:00

abstract：:Hydrochlorothiazide (HCTZ)-induced pulmonary disease has been described as either an allergic interstitial pneumonitis or a cause of noncardiogenic pulmonary edema. The mechanism of this rare life-threatening side effect is largely unknown. Many patients show peripheral leukopenia and extensive immunologic studies rev...

journal_title：Chest

authors： Darwish OS,Criley J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The study aimed to evaluate the effect of upper extremity resistance training for patients with COPD on dyspnea during activity of daily living (ADL), arm function, arm exercise capacity, muscle strength, and health-related quality of life (HRQL). METHODS:Patients were randomly assigned to an intervention o...

journal_title：Chest

authors： Janaudis-Ferreira T,Hill K,Goldstein RS,Robles-Ribeiro P,Beauchamp MK,Dolmage TE,Wadell K,Brooks D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Severe pneumonia requiring ICU admission has not been well characterized with respect to long-term outcomes or predictors thereof. We examined the association between premorbid functional status and mortality in patients with severe pneumonia. METHODS:From 2000 to 2002, a population-based cohort of adults w...

journal_title：Chest

authors： Sligl WI,Eurich DT,Marrie TJ,Majumdar SR

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited to advanced stages of the disease. The objective of this study was to descri...

journal_title：Chest

authors： de Torres JP,Bastarrika G,Zagaceta J,Sáiz-Mendiguren R,Alcaide AB,Seijo LM,Montes U,Campo A,Zulueta JJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and health-care-associated pneumonia (HCAP). These infections are associated with significant morbidity, mortality, and cost. The impact of vancomycin minimum inh...

journal_title：Chest

authors： Haque NZ,Zuniga LC,Peyrani P,Reyes K,Lamerato L,Moore CL,Patel S,Allen M,Peterson E,Wiemken T,Cano E,Mangino JE,Kett DH,Ramirez JA,Zervos MJ,Improving Medicine through Pathway Assessment of Critical Therapy of Hospital-Acqu

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In observational studies using acute lung injury (ALI) as an outcome, a spectrum of lung injury and difficult-to-interpret chest radiographs (CXRs) may hamper efforts to uncover risk factor associations. We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on cli...

journal_title：Chest

authors： Shah CV,Lanken PN,Localio AR,Gallop R,Bellamy S,Ma SF,Flores C,Kahn JM,Finkel B,Fuchs BD,Garcia JG,Christie JD

更新日期：2010-11-01 00:00:00

abstract：:Angiofollicular lymph node hyperplasia, known more commonly as Castleman disease, is a rare lymphoproliferative disorder. Castleman disease has two distinct clinical manifestations described as unicentric and multicentric disease. These presentations have distinct treatment algorithms and portend very different progno...

journal_title：Chest

authors： Bandera B,Ainsworth C,Shikle J,Rupard E,Roach M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Low-density gas mixtures and oxygen (O₂) supplementation are known to improve physical performance and ventilatory adaptation during incremental maximal exercise in COPD. We investigated whether their combined use during intense physical training is also effective in ameliorating exercise tolerance in patien...

journal_title：Chest

authors： Scorsone D,Bartolini S,Saporiti R,Braido F,Baroffio M,Pellegrino R,Brusasco V,Crimi E

更新日期：2010-11-01 00:00:00

abstract：:Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSC) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardial infarction, and more recently, acute lung injury (ALI). This article provides a brief review of the biologic qualities o...

journal_title：Chest

authors： Matthay MA,Thompson BT,Read EJ,McKenna DH Jr,Liu KD,Calfee CS,Lee JW

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:A serum galactomannan (GM) assay has been approved for diagnosing invasive aspergillosis (IA). However, the role of the BAL-GM assay has not been well established. Therefore, we conducted a metaanalysis to determine the overall accuracy of BAL-GM in the diagnosis of IA. METHODS:After a systematic review of ...

journal_title：Chest

authors： Guo YL,Chen YQ,Wang K,Qin SM,Wu C,Kong JL

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high yield for lymph node staging of lung cancer. The aim of this study was to assess the utility of sonographic features of lymph nodes during EBUS-TBNA for the prediction of metastasis in p...

journal_title：Chest

authors： Fujiwara T,Yasufuku K,Nakajima T,Chiyo M,Yoshida S,Suzuki M,Shibuya K,Hiroshima K,Nakatani Y,Yoshino I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Spontaneous pneumothorax (SPTX) is an uncommon phenomenon in the general population and is most commonly associated with prior bulbous emphysema, cystic parenchymal lung disease, and tuberculous lung disease. A rare cause of SPTX is malignant disease, either in the form of primary lung or pleural cancers, or...

journal_title：Chest

authors： Hoag JB,Sherman M,Fasihuddin Q,Lund ME

更新日期：2010-09-01 00:00:00

abstract：:The upregulation of nitric oxide (NO) by inflammatory cytokines and mediators in central and peripheral airway sites can be monitored easily in exhaled air. It is now possible to estimate the predominant site of increased fraction of exhaled NO (FeNO) and its potential pathologic and physiologic role in various pulmon...

journal_title：Chest

authors： Barnes PJ,Dweik RA,Gelb AF,Gibson PG,George SC,Grasemann H,Pavord ID,Ratjen F,Silkoff PE,Taylor DR,Zamel N

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Lowest receptor occupancy for a drug occurs at trough prior to the next dose. Previous studies have focused on the effects of triple therapy at peak dose intervals using forced expiratory maneuvers. Impulse oscillometry (IOS) and body plethysmography (PLETH) are more sensitive than spirometry to assess inhal...

journal_title：Chest

authors： Williamson PA,Short PM,Clearie KL,Vaidyanathan S,Fardon TC,Howaniec LJ,Lipworth BJ

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Great variability exists in the occurrence of antibiotic-resistant bacteria in ICUs around the world. The contribution of specific ICU care variables to these geographic variations is unknown. METHODS:ICU patients from two ICUs (in Jerusalem and Toronto) who were admitted for > 48 h and who grew a resistant...

journal_title：Chest

authors： Levin PD,Simor AE,Moses AE,Sprung CL

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:We suspected, based on clinical experience, that the prevalence of both intracardiac and pulmonary arteriovenous malformations (PAVMs) is higher than previously reported in a healthy population when using modern ultrasound technology combined with a rigorous saline contrast echocardiogram (SCE) protocol. We ...

journal_title：Chest

authors： Woods TD,Harmann L,Purath T,Ramamurthy S,Subramanian S,Jackson S,Tarima S

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify the CT scan features that predict patient outcome after reexpansion procedures in patients with the fibrotic stage of endobronchial TB. METHODS:We retrospectively enrolled 30 patients (four men, 26 women) aged 32 +/- 11 years who had lobar or whole-lung atelectasis ...

journal_title：Chest

authors： Lee JY,Yi CA,Kim TS,Kim H,Kim J,Han J,Kwon OJ,Lee KS,Chung MJ

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate patients with stage I non-small cell lung cancer (NSCLC) and tumors up to 3 cm in maximum dimension who underwent surgical resection on the revised TNM classification and to investigate the risk factors for recurrence. METHODS:Between 1994 and 2003, 713 consecutive ...

journal_title：Chest

authors： Maeda R,Yoshida J,Ishii G,Hishida T,Aokage K,Nishimura M,Nishiwaki Y,Nagai K

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Little information exists about the expected time to death after terminal withdrawal of mechanical ventilation. We sought to determine the independent predictors of time to death after withdrawal of mechanical ventilation. METHODS:We conducted a secondary analysis from a cluster randomized trial of an end-o...

journal_title：Chest

authors： Cooke CR,Hotchkin DL,Engelberg RA,Rubinson L,Curtis JR

更新日期：2010-08-01 00:00:00

abstract：:Various malformations of the aortic arch and great vessels have been reported in the literature, which reflects the complexity of their embryologic development. Most of them are of incidental finding and remain asymptomatic but can be responsible for respiratory or digestive symptoms and be associated with congenital ...

journal_title：Chest

authors： Verin AL,Creuze N,Musset D

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has been documented to cause community-acquired pneumonias (CAP), notable for necrotizing features. The frequency of occurrence, risk factors, and optimal treatment of CA-MRSA CAP are unclear. METHODS:This was a retrospective analysis ...

journal_title：Chest

authors： Lobo LJ,Reed KD,Wunderink RG

更新日期：2010-07-01 00:00:00

abstract：:Acute left ventricular (LV) dysfunction is common in the critical care setting and more frequently affects the elderly and patients with comorbidities. Because of increased mortality and the potential for significant improvement with early revascularization, the practitioner must first consider acute coronary syndrome...

journal_title：Chest

authors： Chockalingam A,Mehra A,Dorairajan S,Dellsperger KC

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Few data are available on the long-term outcome of noninvasive positive pressure ventilation (NPPV) for obesity hypoventilation syndrome (OHS). This study was designed to determine long-term survival, treatment adherence, and prognostic factors in patients with OHS in whom NPPV was initiated in an acute sett...

journal_title：Chest

authors： Priou P,Hamel JF,Person C,Meslier N,Racineux JL,Urban T,Gagnadoux F

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Walking is a familiar daily activity that is generally limited by breathlessness, whereas cycling is an uncommon physical effort typically limited by leg discomfort. The hypothesis was that patients with COPD would exhibit greater improvements in exercise endurance and relief of breathlessness with bronchodi...

journal_title：Chest

authors： Zhang X,Waterman LA,Ward J,Baird JC,Mahler DA

更新日期：2010-06-01 00:00:00

abstract：:The incidence of congenital heart disease is approximately 8/1,000 live births and appears to be constant around the world. The currently accepted paradigm for the development of pulmonary vascular disease associated with congenital heart disease maintains that increased pulmonary blood flow and pressure trigger unfav...

journal_title：Chest

authors： Adatia I,Kothari SS,Feinstein JA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Architectural design of health-care facilities can influence patient safety; however, it is unknown whether patient outcomes are significantly affected by ICU design. METHODS:Six hundred sixty-four patients admitted to the medical ICU (MICU) of Columbia University Medical Center during 2008 were included in...

journal_title：Chest

authors： Leaf DE,Homel P,Factor PH

更新日期：2010-05-01 00:00:00

abstract：:Spontaneous pneumomediastinum is an uncommon benign condition that is occasionally associated with air within the spinal canal. We describe a further case in a 14-year-old girl and suggest a classification system based on a detailed review of the previous literature. Forty-eight patients with spontaneous pneumomediast...

journal_title：Chest

authors： Belotti EA,Rizzi M,Rodoni-Cassis P,Ragazzi M,Zanolari-Caledrerari M,Bianchetti MG

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Patients with COPD are at risk for cardiovascular events. This is attributed to increased systemic inflammation. The course of COPD is punctuated by exacerbations, which further increase systemic inflammation, but the risk of vascular events in the postexacerbation period has never been defined. METHODS:We a...

journal_title：Chest

authors： Donaldson GC,Hurst JR,Smith CJ,Hubbard RB,Wedzicha JA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is associated with a high risk of stroke. The contribution of arrhythmia to events is clear in sustained forms of AF, but in paroxysmal AF, presently available data have yet to identify what proportion of time spent in AF (ie, arrhythmia burden [AFB]) is of clinical relevance. We aim...

journal_title：Chest

authors： Watson T,Arya A,Sulke N,Lip GY

更新日期：2010-04-01 00:00:00

abstract：:A man with usual interstitial pneumonia (age of onset 58 years) was previously found to have an Ile73Thr (I73T) surfactant protein C (SFTPC) mutation. Genomic DNA from the individual and two daughters (aged 39 and 43 years) was sequenced for the I73T mutation and variations in ATP-binding cassette A3 (ABCA3). All thre...

journal_title：Chest

authors： Crossno PF,Polosukhin VV,Blackwell TS,Johnson JE,Markin C,Moore PE,Worrell JA,Stahlman MT,Phillips JA 3rd,Loyd JE,Cogan JD,Lawson WE

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Induced sputum cytology and protein biomarkers can be used to assess airways inflammation. Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers. METHODS...

journal_title：Chest

authors： Gray RD,Duncan A,Noble D,Imrie M,O'Reilly DS,Innes JA,Porteous DJ,Greening AP,Boyd AC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The measure of sputum eosinophil counts is a useful tool in the investigation of occupational asthma (OA), but processing sputum is time consuming. Measuring the fractional concentration of exhaled nitric oxide (FENO) may be an alternative in clinical practice. The aim of this study was to assess the respect...

journal_title：Chest

authors： Lemière C,D'Alpaos V,Chaboillez S,César M,Wattiez M,Chiry S,Vandenplas O

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:This study investigated sites of nitric oxide (NO) gas exchange and response to inhaled corticosteroids (ICS) in patients with COPD and varying extents of emphysema. METHODS:This was a prospective, randomized, single-blind, crossover study in treated, stable, ex-smoking patients with COPD who were ICS and l...

journal_title：Chest

authors： Gelb AF,Flynn Taylor C,Krishnan A,Fraser C,Shinar CM,Schein MJ,Osann K

更新日期：2010-03-01 00:00:00

abstract：:The issue of tobacco industry responsibility for population health problems and compensation for their treatment has been growing since the 1960s. In 1999, the state attorneys general collectively launched the largest class action lawsuit in US history and sued the tobacco industry to recover the costs of caring for s...

journal_title：Chest

authors： Jones WJ,Silvestri GA

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Limited data are available on the impact of time to ICU admission and outcomes for patients with severe community acquired pneumonia (CAP). Our objective was to examine the association of time to ICU admission and 30-day mortality in patients with severe CAP. METHODS:A retrospective cohort study of 161 ICU ...

journal_title：Chest

authors： Restrepo MI,Mortensen EM,Rello J,Brody J,Anzueto A

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) has been reported to be associated with increased values of exhaled nitric oxide (ENO), which could not be entirely explained by the association between CRS and asthma. The aim of this study was to investigate the variables associated with increased ENO in patients with CRS. MET...

journal_title：Chest

authors： Guida G,Rolla G,Badiu I,Marsico P,Pizzimenti S,Bommarito L,De Stefani A,Usai A,Bugiani M,Malinovschi A,Bucca C,Heffler E

更新日期：2010-03-01 00:00:00